WHO guidelines on fluid resuscitation in children: missing the FEAST data

WHO guidelines on fluid resuscitation in children: missing the FEAST data

Sarah Kiguli consultant paediatrician , Samuel O Akech research fellow , George Mtove research fellow , Robert O Opoka consultant paediatrician , Charles Engoru consultant paediatrician , Peter Olupot-Olupot consultant paediatrician , Richard Nyeko consultant paediatrician , Jennifer Evans consultant paediatrician , Jane Crawley consultant paediatrician , Natalie Prevatt research fellow , Hugh ...

Guidelines for prehospital fluid resuscitation in the injured patient.

Although the need and benefit of prehospital interventions has been controversial for quite some time, an increasing amount of evidence has stirred both sides into more frequent debate. Proponents of the traditional "scoop-and-run" technique argue that this approach allows a more timely transfer to definitive care facilities and limits unnecessary (and potentially harmful) procedures. However, ...

Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial

BACKGROUND Early rapid fluid resuscitation (boluses) in African children with severe febrile illnesses increases the 48-hour mortality by 3.3% compared with controls (no bolus). We explored the effect of boluses on 48-hour all-cause mortality by clinical presentation at enrolment, hemodynamic changes over the first hour, and on different modes of death, according to terminal clinical events. We...

European guidelines on resuscitation.

Causes of death after fluid bolus resuscitation: new insights from FEAST

The Fluid Expansion as Supportive Therapy (FEAST study) was an extremely well conducted study that gave unexpected results. The investigators had reported that febrile children with impaired perfusion treated in low-income countries without access to intensive care are more likely to die if they receive bolus resuscitation with albumin or saline compared with no bolus resuscitation at all. In a...